He came back to haunt the West Yorkshire side in 1971 - scoring in a 0-3 United win.
The Red Devils will then welcome Tottenham Hotspur to Old Trafford in the league next weekend, before the small matter of a trip to Chelsea on November 5.
The Portuguese manager received heavy criticism for his perceived negative tactics against Jurgen Klopp'sLiverpool side, but his team hasn't struggled to score so far this season, netting 17 times in just eight league games, and a further eight times in three Champions League games.
Huddersfield started the season in fine form, bagging back-to-back victories for the Premier League newboys.
The striker, who scored 237 goals for United, started his career with the Terriers in 1962. One of my favourite bets on Manchester United games though is corner early.
As for United, Zlatan Ibrahimovic, Paul Pogba and Marcos Rojo remain on the sidelines, but Marcus Rashford has been cleared to play after recovering from the knee injury he picked up in the latter stages of the clash with Benfica.
Following a bright start to the season, which included wins over Newcastle United and Crystal Palace, Huddersfield are on a six-game winless streak and have dropped to 12th.
Marcus Rashford netted the only goal of the game to keep United's 100 per cent Champions League record intact.
Collin Quaner and Kasey Palmer, meanwhile, are still unavailable due a calf problem and hamstring injury respectively.
Despite United's recent dip in performances, and the fact that Huddersfield will be much fresher than Mourinho's men, it should be a comfortable win for the visitors.