While United have turned their season around with 10 wins from 11 games since Solskjaer replaced Jose Mourinho, runaway Ligue 1 leaders PSG slipped up last week against Lyon and scraped to a 1-0 win over Bordeaux on Saturday thanks to an Edinson Cavani penalty.
But while Buffon believes the sides are on level pegging heading into the clash, things could have been different if PSG hadn't lost Neymar to injury, while Cavani is also a doubt after picking up a knock against Bordeaux.
The Uruguay worldwide was one of few PSG stars to start the match, as Tuchel kept the likes of Leandro Paredes and Kylian Mbappe in reserve ahead of the last-16 first leg at Old Trafford.
The came the injury to midfielder Marco Verratti. It's very hard if we play with our best team, it's a big challenge. "Yes, there has been a lot of bad luck - we do not have a second Edi, or Neymar".
'I honestly don't know if Cavani will play. "But we're ready for Manchester and I have faith in my players".
"If he comes off, obviously I am anxious. But we have to wait for the doctor's opinion to see if it's possible or not".
While Tuchel needs Verratti against a United midfield featuring the in-form Paul Pogba, the 58 minutes he played may not be enough to get his rhythm back in time to face a revitalized United.