The Queen has held her role with the National Theatre for 45 years and after 33 years, the monarch is also handing over her role with The Association of Commonwealth Universities to Meghan.
The former actress' support for the National Theatre reflects her belief in using the arts to bring communities together and her own background in theater and television, the palace said.
In addition, Meghan will become patron of two additional charities: Smart Works, which helps vulnerable women find the skills needed to work, and Mayhew, a grassroots organization active in London and internationally.
"Meghan has so much on her plate, between being pregnant and dealing with the public backlash, and she's finding the whole situation incredibly stressful", a royal insider explained.
Meghan, who Wednesday Prince Harry in May, will now assume her role as the royal patron of several charitable organisations. A source also told People back in September that the duchess "spends most of her weekends" there.
The Palace confirms that Markle has had private meetings with all of these organizations for the past year.
Within a couple of hours of the announcement by Kensington Palace the duchess visited one of the organisations, Smart Works, which helps vulnerable women gain employment.
"The Duchess shares our passion for the transformational power of higher education, and Her Royal Highness' support will help champion higher education as a force for good in the Commonwealth and beyond", she said. "We would like to thank Her Majesty The Queen for her support, and we look forward to working closely with The Duchess as our Patron". "Mayhew works to improve the lives of dogs, cats and the people in our community".
News of Meghan's difficulty handling the negative press comes after reports Prince Harry has been "frustrated" about not being able to protect his wife from the downfalls of being a member of the royal family.