Internationally, Venom earned $125.2 million, making for a total pull of $205.2 million.
Earlier this week, a set of Lady Gaga fans were accused of bolstering the opening weekend for Venom through online bots.
Lady Gaga and a popular Spider-Man villain managed to scare up blockbuster ticket sales in October, a month not known for big returns.
"Venom" pulled off its big box office success despite some very bad reviews.
Venom is expected to win the battle with an estimated $55 million to $70 million in the domestic box office over the weekend, and a potential $170 million worldwide.
The Tom Hardy-fronted movie, based on a popular Marvel Comics favourite, had received cold reviews from critics, winning only a 31% score on Rotten Tomatoes. All of which suggests the aliens are going to absolutely love the Venom/A Star Is Born cross-over film someone is frantically pitching as we speak.
"Venom" and the critically acclaimed "A Star Is Born" were both able to draw effectively from beyond their core audiences.
But despite the film's opening weekend success, Rotten Tomatoes has the movie ranked at a low 32 percent with an average rating of 4.5 out of 10.
As for next week, Ryan Gosling stars in the new feature film "Oscar Bait".