The score was a true reflection: for the first two sets, it was slaughter in the sun; the third set was well contested but Nadal's progress was never in doubt.
A year ago, Federer became the first man since Bjorn Borg in 1976 to win the title without dropping a set.
The 6-1 6-2 6-4 triumph ensured Nadal reached the fourth round at the All England Club for an eighth time. I just feel like it's not really what you do in a practice with other guys. "You have to win the last point, and I didn't succeed in that today". Playing without fear, Tsitsipas is the first Greek man to reach the fourth round at any major in the Open Era.
"All these problems that I am going through during my career. makes me enjoy more the good moments".
Milos Raonic's match against Dennis Novak was suspended due to fading light in the third set, with Raonic leading 7-6 (5), 4-6, 6-5.
Van Uytvanck will meet Russian 14th seed Daria Kasatkina, who beat Australia's Ashleigh Barty 7-5, 6-3.
Federer is having no such problems and eased past Jan-Lennard Struff 6-3 7-5 6-2.
Seven of Williams' 23 Grand Slam singles titles have come at the All England Club, including the last two times she played in the grass-court tournament, in 2015 and 2016.
Third seed Cilic could have met Federer in the last four but crashed out in the second round to Argentinian Guido Pella, in one of the biggest shocks of the tournament.
The 38-year-old American, last year's runner-up, was the oldest women's singles entrant in 2018.
Day 7 at Wimbledon is unique, as all 32 remaining players across the men's and women's draw are in action on the same day. Just pretty insane, " said McDonald, who grew up in California, and now is based at the U.S. Tennis Association's main training facility in Florida.
The Czech faces Dutch 20th seed Kiki Bertens, who stunned five-time Wimbledon victor Venus in the third round.
Ninth-seeded John Isner of the US reached Wimbledon's fourth round for the first time, beating 98th-ranked Radu Albot of Moldova 6-3, 6-3, 6-4.
Isner hit 21 aces and never faced a break point.
The eight-time champion will face French 22nd seed Adrian Mannarino on Monday for a place in the quarter-finals.