Saturday, 22 September, 2018

Herpes Virus May Be Involved In Alzheimer’s Disease

Herpes Virus May Be Involved In Alzheimer’s Disease Herpes Virus May Be Involved In Alzheimer’s Disease
Melissa Porter | 26 June, 2018, 16:49

Neuroscientist Keith Fargo of the Alzheimer's Association, not involved in the research, tells Rosenbaum that a lot of genetic factors are also at play in the disease, and it will take more studies to untangle how immune reactions, genetics and other factors play into its progression. After an 18-month study examining the effects of nutritional compounds found in foods such as trout, broccoli and peppers on people with Alzheimers, the team from the Nutrition Research Centre Ireland (NRCI) claims to have done a ‘statistically significant finding.

Recall that a virus the herpes infected nearly everything.

The study was published today and indicates that researchers discovered that the brains of deceased people who had Alzheimer's disease had more viruses than brains of people without the disease.

Scientists have found up to two times higher level of human herpes virus among people with Alzheimer's disease, suggesting the potential role of the viruses in the development of the progressive brain disorder. These viruses might then influence the manner in which Alzheimer's develops further. "It therefore doesn't change what we already know about the causes of dementia, doesn't mean that having cold sores put you at increased risk of getting it and people shouldn't be unduly anxious". Presence of these antibodies indicated the encounters of the person with this virus sometime during their lives.

However, since the strains were discovered in both Alzheimer's brain tissue and non-Alzheimer's brain tissue, it is quite hard for the researchers to ascertain that Alzheimer's disease is primarily caused by the viruses.

Role in the manifestation of Alzheimer's disease is likely to be played by herpesviruses, a theory that has been formulated for years and is now reinforced by new American scientific research. "If viral infections are playing a part, they are not the sole actor". In the course of course they can cause encephalitis and other chronic conditions. Gandy said that the Alzheimer's genes were apparently being "modulated" by the HHV6/7 and so it could be the viral proteins that could be turning on the genes responsible for Alzheimer's disease. About 90 percnet of adults have been exposed to the herpes virus by age 50, research shows, and not all of them will go on to develop dementia. These viruses often have no symptoms, infect many people in their childhood and will stay dormant in the human body.

The study is by no means conclusive evidence that the viruses cause Alzheimer's. Gandy also said these findings could open new avenues of research for treatment of the disease but at present risk susceptibility for the disease is still not clearly understood. They began their direct investigation of viral sequences using data from the Mount Sinai Brain Bank and were able to verify their initial observations using datasets from the Religious Orders Study, the Memory and Aging Project and the Mayo Clinic Brain Bank.