After Oprah firmly explained the talkativeness of her co-stars from A Wrinkle In Time, as well as her intense dislike of gum chewing, Colbert joked, "are you going to yell through this entire interview?"
After God confessed to being a big fan of Winfrey's, she chuckled, "That's great to hear".
"All I can say, God, is that running is now part of my exercise routine, I can tell you that", Winfrey chuckled.
"I'm a huge fan", said the cartoon of God projected on the stained-glass dome atop the Ed Sullivan Theater in NY.
"Oh yeah. I hear thou seekest a sign?" God asked Oprah before proceeding to hold up an actual sign reading, "Run!" "There are a lot of people out there who would like to see you be President of the United States", Colbert said. "Oprah", she told him. "People never leave money for the housekeepers in a hotel (and) I usually just leave the money on the pillow, but this time I put it all over the room: under the desk, on the counter with the M&Ms, in the shower".