Performances for the night included Ed Sheeran, who provided a raw rendition of "Supermarket Flowers" from his album Divide, and Stormzy, who delivered a rain-soaked rendition of his hit "Blinded By Your Grace Pt 2".
Lipa was accompanied by dozens of dancers, also scattered throughout the arena.
Lipa dedicated her solo artist trophy to all the female musicians who "have allowed us to dream this big".
The performance got the attention of Britain, with Stormzy's performance taking centre stage of the BRIT awards on Wednesday evening. While presenting at the ceremony, Ellie Goulding, who was clutching a white rose, saluted the women who had taken up the cause at the Brit Awards, stating, "It's so fantastic to see so many women wearing roses".
"It does make a difference", Lipa told Reuters on the red carpet of the protest.
The Brit Awards have recognised the cream of British pop music since they were first held in 1977, but in recent years have been criticised for failing to be bold.
Kendrick Lamar won a Brit too for best global male solo artist and Lorde scooped a Brit for best worldwide female solo artist.
Following the release of their album Humanz, they won best British Group, beating the xx, Royal Blood, Wolf Alice and London Grammar. He thanked "everyone back in Brighton" and "everyone who has had my back over the years".
Stormzy has been praised by Jeremy Corbyn and fellow Labour MPs after he asked Theresa May "where's the money for Grenfell?" in his live performance at the Brit Awards.