"My prayers and best wishes are with the family of Edwin Jackson, a wonderful young man whose life was so senselessly taken", Trump also tweeted.
Trump is also prodding Democrats to work with him on illegal immigration and border security.
A little more than two years later, in March 2009, he was again arrested in San Francisco and then deported that May. He was deported to Guatemala a second time in May 2009.
Meyer said his office prosecuted Orrego-Savala in August 2017 under the false identity of Alex Cabrera Gonsales, the same alias he gave to the Indiana State Police after being arrested for the crash Sunday.
Neither the federal complaint or local court documents shed light on when Orrego-Savala re-entered the US or when - or why - he traveled to Indiana.
Manuel Orrego-Savala, 37, is facing charges of failure to remain at the scene of an accident and two counts tied to the drunken driving death.
The judge entered a not guilty plea on his behalf and set bond at $200,000.
His defence attorney, Jorge Torres, said Orrego-Savala's immigration status has no bearing on the drunken-driving case and questioned whether his client could get a fair trial given his immigration issues.
The crash highlights the need for building a U.S. -Mexico border wall, "ending sanctuary cities and stopping illegal immigration once and for all", he said in a statement.
Studies over the last few decades have not supported Trump's suggestion that immigrants who are in the country illegally are more likely to commit crimes.
Jackson played 16 games with the Colts in 2016 but spent the previous year on injured reserve.
"We admired his outgoing personality, competitive spirit and hard-working mentality", the Colts said in a release.
In a statement, the Colts said Jackson "always brought a smile to our locker room and the community".
Police in Whitestown, Ind. pulled over Orrego-Savala after he failed to stop at a stop sign, reports the Indianapolis Star. Investigators said Jackson, 26, and his Uber driver, 54-year-old Jeffrey Monroe, were standing outside Monroe's vehicle when they were struck and killed by a pickup truck driven by Orrego-Savala. One of the men was thrown into the center lane.
Indiana State Police say early Sunday morning, Orrego-Savala crashed a pick-up truck into two men stopped on in the emergency shoulder on I-70. A portable breath test administered at the scene determined Orrego-Savala's BAC to be 0.239 percent - three times the legal limit.
It was not immediately clear when Orrego-Savala re-entered the US after being deported in 2009. Cabrera Gonsales was arrested and accused of operating a vehicle while never receiving a license, and was handcuffed and taken to Boone County Jail for further processing.