Sunday, 18 November, 2018

Greek scientist created a diagnosis test of 8 types of cancer

Researchers Develop Single Blood Test that Screens for Eight Cancer Types Researchers Develop Single Blood Test that Screens for Eight Cancer Types
Melissa Porter | 21 January, 2018, 02:56

The ultimate aim of the scientists is to have a blood test that everybody will take every year so that any type of cancer can be diagnosed early enough to increase the likelihood of cure and survival.

"The use of a combination of selected biomarkers for early detection has the potential to change the way we screen for cancer, and it is based on the same rationale for using combinations of drugs to treat cancers", says Dr. Nickolas Papadopoulos, senior author and professor of oncology and pathology.

The test can be used to determine eight types of cancer which are the most common types, ovarian, liver, stomach, pancreatic, oesophageal, colorectal, lung and breast cancers.

When cancerous tumors form, they release small fragments of mutated DNA and proteins into the bloodstream, and these can act as markers for cancer. These include breast, lung, and, as well as five cancers - ovarian, liver, stomach, pancreatic, and esophageal - for which there are now no routine screening tests for people at average risk.

"This field of early detection is critical, and the results are very exciting", said Cristian Tomasetti from the Johns Hopkins University School of Medicine. The median overall sensitivity, or the ability to find cancer, was 70 percent and ranged from a high of 98 percent for ovarian cancer to a low of 33 percent for breast cancer. Sensitivity ranged from 69 percent to 98 percent for the five cancers that now have no routine screening tests, the researchers report. The test was used on 812 healthy controls and produced only seven false-positive results.

An example is the comment of Dr. Gert Attard, the team leader at the Centre for Evolution and Cancer at the Institute of Cancer Research, London, United Kingdom, who is also a consultant medical oncologist at the Royal Marsden NHS Foundation Trust, on the discovery.

Professor Richard Marais, a researcher at the Cancer Research UK, also relayed his opinion on CancerSEEK, "Detecting cancer early, before the disease has spread, is one of the most powerful ways to improve cancer survival and this interesting research is a step towards being able to do this earlier than is now possible". They sought more than a thousand people who have been diagnosed with the aforementioned cancers.

To precisely determine the optimal number of DNA bases to assess in the CancerSEEK test, the researchers used a method based on diminishing returns.

However, the Johns Hopkins researchers believe that CancerSEEK could bring us closer to a quick, simple way to detect cancer in its early stages. "This has the potential to substantially impact patients". "I'm enormously excited. This is the Holy Grail - a blood test to diagnose cancer without all the other procedures like scans or colonoscopy".

They envision that the CancerSEEK test will eventually cost less than $500.