The Raiders and Chargers are awaiting construction of new stadiums, and the Jaguars have a long-term agreement to play in London to combat low local revenues in Jacksonville. The game will be at the new Tottenham Hotspur Stadium.
The Seahawks will have their longest-ever road trip next season. Tennessee will be considered the road team in the final London showdown. London games typically start at 6:30 a.m.
The Redskins will not get to follow up their 2016 London game against the Bengals in 2018. The NFL invested $12.8 million in the venue, which has a total cost of more than $1 billion.
On why they are only staging one game here this year, London mayor Sadiq Khan said it was because Spurs and the National Football League are "perfectionists" and want to get everything right first time around.
The Jaguars, regulars on the London circuit, will "host" the Eagles in one game.
To register for NFL London 2018 tickets all you need is your basic details and to state which game you're interested in attending.
This will be the Chargers' sixth game overseas in franchise history and second in the regular season. They'll host the Eagles at Wembley Stadium. The Eagles won the NFC East, and hopefully by the time they hit London next season quarterback Carson Wentz will be back from a knee injury. The Chargers were probably the best team to not make the playoffs this season, and the Titans made it and won a wild-card game last week.
The league has played three games in London each of the past three seasons.
"It has been 10 years since we last played in London, and other than the outcome of the game back in 2008, the experience there among the worldwide fans was pretty cool", said Chargers quarterback Philip Rivers.
The long-term ambition, however, must be for Spurs to become the full-time home of a London franchise and chairman Daniel Levy told reporters at the club's headquarters that he "hoped" this would be the case.