Tuesday, 11 December, 2018

80% of His Skin Had Been Lost. Doctors Grew Him a Replacement

80% of His Skin Had Been Lost. Doctors Grew Him a Replacement 80% of His Skin Had Been Lost. Doctors Grew Him a Replacement
Melissa Porter | 11 November, 2017, 15:23

Almost two years later, the boy's new skin has gone through 20 monthly renewal cycles, and heals and stretches just like a healthy epidermis.

As a final attempt, the doctors contacted Michele de Luca, director of the Center for Regenerative Medicine at the University of Modena and Reggio Emilia in Italy.de Luca had previously done a similar skin graft on legs, but nothing of this scale. Skin has several layers upon layers of cells or epidermis. Just when it seemed like a 7-year-old boy admitted at a medical facility in Ruhr University in Bochum, Germany was on the brink of death, skin genetics came to the rescue. Why do I have to live this life?

He's back to school, he's exercising, he's started to play soccer.it's quite unbelievable. "I couldn't answer these questions". Holoclar, a treatment that replaces the eye's cornea in a form of blindness, became the world's first commercial stem-cell therapy in 2015.

"It was a tough decision for us, but we wanted to try for (our son)", the boy's father said.

The "butterfly child" who lost 80% of his skin has been successfully treated. But a piece of Hassan's skin was taken, repaired in a laboratory, and grafted back onto his body. The engineered skin cells and stem cells were then used to grow skin in the lab.

In total, they grew close to a square meter of skin (3 square feet.) The lab-grown skin was then transplanted onto the boy in three operations, ultimately covering 80 percent of his body.

Doctors treating a critically ill boy with a devastating skin disease used experimental gene therapy to create an entirely new skin for him.


The technique "marks a major step forward" in the field of gene and stem cell therapy, experts Mariaceleste Aragona and Cedric Blanpain wrote in a comment on the study.

So far, no problems have been detected.

This highlights the huge potential that this approach has for the treatment of epidermolysis bullosa and other severe skin diseases. And now the kid is back to school, he's playing soccer, and spending holidays with his siblings. "That's what we dreamed of doing and it was possible". He was missing large areas of skin that made him exceptionally vulnerable to infections and other complications. The result is skin that readily blisters, causing large, chronic wounds and vast pain to the patient. Surgeons in Germany sent a skin biopsy to Modena, and two major skin transplants followed.

In this photo taken on October 18, 2017, doctors lift up a sheet of skin in a lab at St Josef-Hospital in Bochum, Germany.

"Both theories were valid, but what had been lacking was real proof in vivo, in patients", says Aiuti.

Since arriving in Germany with his family, the boy's condition had significantly deteriorated-De Luca suspects because of the family's distressing relocation, the resulting lack of consistent clinical care, and the family's language difficulties.

"The parents are very grateful and say their life has completely changed", De Luca said, recalling how the boy spontaneously began taking off his clothes. In the months that followed, skin biopsies from the boy showed that his new skin adhered firmly to the underlying dermis, and had normal morphology and levels of laminin b3. The AP is exclusively responsible for all content.