Thursday, 19 April, 2018

New skin patch created to reduce fat by 20 percent

Skin patches that release fat-burning drugs directly into areas on the body could help with problems such as love handles. Researchers from Columbia University and University of North Carolina tested the patches on mice and found they lost 20 percent of New skin patch created to reduce fat by 20 percent
Melissa Porter | 17 September, 2017, 15:36

This conversion apparently takes place in the part of the body where the patch is located, meaning it could (assuming it proves effective for humans) be used to treat the small pockets of fat that people typically get liposuction treatment for.

"The nanoparticles were created to effectively hold the drug and then gradually collapse, releasing it into nearby tissue in a sustained way instead of spreading the drug throughout the body quickly", Gu said in the Columbia release.

When that patch is applied to skin, the needles painlessly pierce its surface, releasing the particles into the underlying fat cells in a sustained fashion. White fat stores excess energy in large triglyceride droplets.

This new centimeter-square device uses nanotechnology to dissolve the bad and unwanted love handles located at the sides of the waistline. Baby fat is primarily brown fat, but as they become adults, most of the brown fat is lost and humans retain the hard-to-lose white fat.

This skin patch makes use of nanotechnology to convert white fat in the body to brown fat that burns energy, boosting the body's metabolism, Tech Times reports. The findings were published on Friday in the journal ACS Nano. (In comparison, a human hair is about 100,000 nm wide.) The nanoparticles are then loaded into a centimeter-square skin patch containing dozens of microscopic needles.

Existing treatments that promote browning must be given as pills or injections, which expose the whole body to the drugs, causing stomach upsets, weight gain and bone fractures.

By contrast, the skin patch circumvents these complications by delivering the drugs directly to the region needed, such as the areas of flesh above the hips.

During trials, patches containing two compounds - either rosiglitazone (Avandia) or beta-adrenergic receptor agonist (CL 316243) - were stuck to obese mice. Each mouse was given two patches-one loaded with drug-containing nanoparticles and another with empty nanoparticles-that were placed on either side of the lower abdomen.

New patches were applied every three days for a total of four weeks. Their fasting blood glucose levels were also significantly lower than untreated mice.

Genetic analyses likewise showed that the treated side has more genes associated with brown fat compared with the untreated side, which suggests that the metabolic changes and fat reduction the researchers observed can be attributed to an increase in the browning process. Additionally, when regular lean mice were treated, their metabolic activity increased by 20 percent.

It also has promise as a treatment for metabolic disorders like diabetes and obesity. But all of these now exist only in pill and injection form.

This new skin patch appears to have mastered the process of browning.