Democrats also lost a special election in SC on Tuesday in a race Republicans were widely expected to win. But in the end RepublicanKaren Handel defeated Democrat Jon Ossoff in a race to replace the vacancy left by President Trump's Health and Human Services appointee Tom Price.
Trump himself weighed in over Twitter Thursday morning with digs at Pelosi and Senate Minority Leader Chuck Schumer of NY. "That would be very bad for the Republican Party", he tweeted. "But I am honored by the support", she said.
The minority leader also responded to Republicanattack ads in Georgia and elsewhere that targeted her record and her San Francisco district.
On MSNBC's "Morning Joe", Ryan predicted it would be hard for Democrats to win back the House with Pelosi as Minority Leader.
Pelosi and the seniority system that congressional Democrats are wedded to are hampering any effort to shake up their party in the Age of Trump. "If we don't, then I think it's incumbent upon her and all of us to reassess who our leadership should be".
President Trump took to Twitter Thursday to weigh in on whether Pelosi should resign.
But it was a demoralizing blow to Democrats hoping Georgia would be a breakthrough for a party trying to harvest electoral victories from the grassroots anti-Trump activism seen in marches on Washington and boisterous crowds at town hall meetings around the country.
Rep. Tim Ryan (R-OH), who challenged Pelosi for the leadership previous year, said on CNN: "The brand is just bad". That makes the party 0-for-4 in this year's races for Republican-held congressional seats.
"There comes a time when every leader has to say, 'For the good of the order and the betterment of the party, it's time for me to step aside.' And I wish that that would happen right now", said Rice.