The ad, created to influence Georgia's special election, casts Griffin as a supporter of Ossoff in an attempt to frame him as the nominee of hysterical out of state liberals, who according to the ad, account for 95 percent of his campaign donations.
Early voting has begun in a nationally watched special congressional race in Georgia.
In Georgia, Ossoff almost won an April 18 primary outright in a field of 18 candidates.
The seat was formerly held by current Health and Human Services Secretary Tom Price. Handel finished second with about 19.8 percent of the vote in the crowded primary, which had 18 candidates on the ballot.
Trump narrowly won the 6th District over Hillary Clinton in November but underperformed Price.
The Democrats haven't been close to winning heading into the other special elections in Kansas and Montana.
The race could be Democrats' best shot at picking up a Republican seat ahead of the 2018 midterm elections.
Early voting for the contest started Tuesday and runs through June 16.
Ossoff has 49% of the vote to Handel's 48%, according to the WSVB-TV/Landmark Communications poll taken this week -- meaning that it's sure to be a nail-biter when constituents head to the polls on June 20. Yet he's lumped in with her, along with images of Michael Moore and sundry window-breaking, car-burning, trashcan-spilling anarchists, as "angry liberals" who "have gone too far" in their determination to foist Ossoff on the clean-living suburbanites of the sixth district.