The team examined the groups of beta cells that contain antigens for autoreactive CD4 T cells in order to isolate autoantigens from type 1 diabetes and discovered a new class of antigens made up of insulin fragments attached to peptides and other proteins that are also observed in beta cells.
The study, funded by the European Union and the JDRF, has been published online in the journal Diabetes.
In other news TimesOfMalta News reported, Noel Morgan said: "This is incredibly exciting, and could open the doors to new treatments for young people who develop diabetes".
Researchers from Denver have identified a new class of antigens that may be contributing to the development of type 1 diabetes.
Privately held Viacyte, which specializes in regenerative medicine, and Johnson & Johnson are collaborating on a stem cell treatment for patients with type 1 diabetes.
A previous study found that the number of American kids with type 1 diabetes has significantly increased, and researchers now don't know why this has happened. Here in Exeter, we now have this incredible resource of a unique biobank of human samples from people with type 1 diabetes, which means we're able to see what's really going on in the human body.
After a decade of research, the cause of Type 1 diabetes may have finally been found. Type 1, not to be confused with adult onset or Type 2 diabetes (which based on diet doesn't wait for adulthood), is an inherited autoimmune disorder which sees insulin-producing beta cells in the pancreas being destroyed by the body's own immune cells.
It activates the T cells which makes them attack the insulin producing cells. Their theory is that something might be happening within beta cells that trigger the attack.
The islets cell transplants and the ability to produce islets from stem cells already exist; the thing unachievable was to protect these cells from an immune attack, which after more research could become possible. His results showed a new type of protein modifier.
"We found a new type of protein modification", Delong told CBS4. The problem is when they get a get a bit confused and start running amok and killing healthy cells in the body rather than concentration on foreign cells. It seems pretty simple, but this could change a life person's forever. It prompted him to find answers for the condition. "Why does my immune system turn against me?'" he said.
Delong and his team won a highly competitive 5-7er grant that is American Diabetes Association's Pathway to Stop Diabetes program. "If we can find a way to reactivate these cells so that they resume insulin release, we may be able to slow or even reverse progression of this bad disease".